基本情况

秦建春 教授 博士生导师

秦建春，澳门尼威斯人唐敖庆特聘教授（领军A），入选国家重大人才支持计划，国家首批“神农英才”入选者，从事天然产物化学，植物保护以及植物代谢调控研究，在德国哥廷根大学完成博士论文(中德联合培养)，澳门尼威斯人生物学流动站博士后，澳门尼威斯人杰出青年科学基金后备人才，吉林省拔尖创新人才，吉林省有突出贡献专家、享受政府特殊津贴，享受吉林省人才“18条”政策，曾经在德国哥廷根大学马普所做访问学者,中国菌物学会药用真菌和菌物化学分委会常委,吉林省植物保护学会理事兼农药委员会副主任主任委员。担任Allelopathy Journal，Natural Product Research, Food Chemistry,  Journal of Agricultural & Food Chemicstry, Boorganic & Medicinal Chemistry Letters等学术期刊的副主编或特邀审稿人。与德国马普所，哥廷根大学，汉堡大学，日本冈山大学，北京协和药植所、中国中医科学院中药研究所，清华大员工命科学学院、北京大学药学院，中国科学院微生物所和昆明植物所等多所世界顶尖大学和科研院所建立合作关系。主持国家自然科学基金等国家和省部级课题10项，在国际期刊发表学术论文超过60多篇，申请多项专利。

联系方式（Contact number）

传真：0431-87835722

Email:qinjc@jlu.edu.cn

教育和培训（Education & Training）

1.从植物和微生物中寻找具有新颖结构和生物活性的化学成分，进一步结构修饰改造来提高活性，用于药物，尤其是生物农药的研发。同时从化员工物学互作角度探索天然产物合成通路进化和生态防御功能。

2.植物和微生物中活性成分的合成生物学研究,对合成基因和通路的解析有助于定向调控、异源表达和高效生产药用成分。

3.植物中黄酮类、甾体类，萜类，生物碱和精油在农业、香水香料、食品、化妆品、染料等领域的应用研究。

2006-2009，西北农林科技大学与德国哥廷根大学化学系，博士（国家建设高水平大学第一批出国联合培养博士，天然产物化学）

2003-2006，西北农林科技大学，生命学院，植物化学，硕士

1997-2001，西北农林科技大学，植物保护学院，植物保护，学士

工作经历（Professional Experience）

2019年10月-11月，日本冈山大学访问交流，团长

2017-至今， 澳门尼威斯人，澳门尼威斯人，教授

2014-2015，德国Georg-August-University of Gottingen，生物有机和分子生物研究中心，国家青年骨干教师国外研修项目，访问学者

2011-2017， 澳门尼威斯人，澳门尼威斯人，副教授

2012-2016，澳门尼威斯人，生物学博士后流动站，博士后

2009-2011，澳门尼威斯人，澳门尼威斯人，讲师

2007-2008，德国哥廷根大学，化学系，联合培养

2001-2003，西部植物化学国家工程研究中心,研究人员

教学（Teaching）

本科生《天然产物化学》，《植物化学》，《植物代谢调控》，《植物药用成分分析》

本科生选修课程《发酵工程》，《生物制药》

研究生主修课程《生物农药》等

主持科研项目（Research Projects）

1.国家自然科学基金面上项目（2022）

2.吉林省科技厅重点研发项目（2022）

3.国家自然科学基金面上项目:（2018）

4.中央本级重大增减支项目（黄璐琦院士主持），（分课题主持）（2018,2022）

5.国家自然科学基金面上项目（2015）

6.国家自然科学基金项目:（2012）

7.国家自然科学基金青年基金项目（2010）

8.中央引导地方发展基金（深圳市,2021）

9.吉林省自然科学基金重点项目（2013）

10.中国博士后科学基金特别资助项目：球毛壳菌产生的嗜氮酮类抗肿瘤活性化合物及其生物合成研究（2013）

11.中国博士后科学基金面上项目：葫芦巴薯蓣皂苷等次生代谢产物生物合成基因研究（2012）

12.澳门尼威斯人国家杰出青年科学基金后备人选培育计划项目：毛壳菌中新颖结构的嗜氮酮类化合物及生物活性研究（2013）

13.澳门尼威斯人科学前沿和交叉学科择优资助项目：长白山有毒大型真菌化学成分及生物农药研究

14.澳门尼威斯人中央财政交叉研究资助项目：超分子纳米材料介导的化员工物学研究和黑土地抗病减污精准用药系统研究

15.澳门尼威斯人青年教师学科交叉培育项目，三种长白山丝膜菌中蒽醌类成分及抗肿瘤活性研究

16.广东丽珠制药集团横向课题,万星类抗生素研发和技术服务

发表论文(Publications)

(1) Jin-ming Gao, Sheng-xiang Yang, Jian-chun Qin. Azaphilones: Chemistry and Biology. Chemical Reviews, 113(7): 4755-4811, 2013（SCI , 影响因子:45.661）

(2) Chao‐Yi Wang  Jie Yang  Jian‐Chun Qin*, Ying‐Wei Yang*. Eco‐Friendly Nanoplatforms for Crop Quality Control, Protection, and Nutrition, Advanced Science,2021, DOI:10.1002/advs.202004525（通讯作者, SCI, IF:17.521）

(3) Chenggang Song, Jian Yang, Yanduo Wang, Gang Ding, Lanping Guo & Jianchun Qini, Yong-Fu Li, Jia-Rui Wu,  Xin-Yue Lou, Junyou Han,  Jianchun Qin*, Mechanisms and transformed products of aflatoxin B1 degradation under multiple treatments: a review,Critical Reviews in Food Science and Nutrition，2022,（通讯作者, IF:11.208）

(4) Xiang-Shuai Li, Yong-Fu Li, Jia-Rui Wu,  Xin-Yue Lou, Junyou Han,  Jianchun Qin*, Ying-Wei Yang*. A color-tunable fluorescent pillararene coordination polymer for efficient pollutant detection. Journal of Materials Chemistry A, 8(10): 3651-3657, 2020（通讯作者, IF:12.732）

(5) Chao‐Yi Wang  Xin-yue Lou, Zhi Cai, Ming-Zhe Zhang, Cheng-guo Jia,  Jian‐Chun Qin*, Ying‐Wei Yang*. Supramolecular Nanoplatform Based on Mesoporous Silica Nanocarriers and Pillararene Nanogates for Fungus Control, ACS Appl. Mater. Interfaces, 2021, 13, 27, 32295–32306（通讯作者, IF:10.383）

(6) Chao‐Yi Wang，Ming-Zhe Zhang, Cheng-guo Jia, Ying‐Wei Yang*, Jian‐Chun Qin*. A Lesion Microenvironment-Responsive Fungicide Nanoplatform for Crop Disease Prevention and Control. Advanced Healthcare Material,2022. （通讯作者, IF:11.092）

(7) Yuqing Liu, Chenggang Song, Ying-Wei Yang*, Jianchun Qin*. High-Performance Functional Fe-MOF for Removing Aflatoxin B1 and Other Organic Pollutants. Adv. Mater. Interfaces 2022, 2102480（通讯作者, IF:6.389）

(8) Chenggang Song, Mingyue Wu, Yanxin Zhang, Jie Li, Jian Yang, Dongsheng Wei, He Li, Lanping Guo,* and Jianchun Qin*. Bioactive Monomer and Polymer Polyketides from Edible Mushroom Cortinarius caerulescens as Glutamate Dehydrogenase Inhibitors and Antioxidants. J. Agric. Food Chem.2022（通讯作者, IF:5.279）

(9) Chenggang Song,Gang Ding, Jinlong Dai, Yanduo Wang, Qi Zhang, Jian Yang, Jianchun Qin*. Anti-aflatoxigenic nano-emulsions based on Monarda didyma and Neopallasia pectinata essential oils as novel green agent for food preservation. Industrial Crops & Products.180 (2022) 114777. （通讯作者, IF:6.449）

(10) Xiangshuai Li ‡, Jianchun Qin‡, Ming Sun, Jiarui Wu, Liancheng Lei, Jing Li,Lei Fang, Ying-Wei Yang*. Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release. Chemical communications, 55(94): 14099-14102, 2019（并列1作, IF：6.164）

(11) Daren Qiu, Jie Guo, Huimei Yu, ShengXiang Yang, Yamei Zhang, Dongsheng Wei, Mingzhe Zhang,Jiangchun Qin*.. Antioxidant phenolic compounds isolated from wild Pyrus ussuriensis Maxim. fruit peels and leaves. Food Chemistry, 241:182-187. 2018 （通讯作者，IF：9.231）

(12) Yan-Duo Wang,Cheng-Gang Song, Jian Yang,Tao Zhou,Yu-Yang Zhao, Lan-Ping Guo, Gang Ding, Jian-Chun Qin,Accurate Identification of Degraded Products of Aflatoxin B1 Under UV Irradiation Based on UPLC-Q-TOF-MS/MS and NMR Analysis. Front. Chem.2021.789249（通讯作者, IF:5.221）

(13) Jie Yang , Dihua Dai , Zhi Cai,Yu-Qing Liu, Jian-Chun Qin, Yan Wang,Ying-Wei Yang. MOF-based multi-stimuli-responsive supramolecular nanoplatform equipped with macrocycle nanovalves for plant growth regulation.Acta Biomaterialia.2021(IF:8.947）

(14) ChengguoJia，Shengke，Zhao，Tingting Bao，Peiqing Zhao， KuanPeng， QingxunGuo， XiangGao*，Jianchun Qin*. Tomato BZR/BES transcription factor SlBZR1 positively regulates BR signaling and salt stress tolerance in tomato and Arabidopsis. Plant Science，302，110719，2021（通讯作者）

(15) Chenggang Song, Jian Yang, Mingzhe Zhang, Gang Ding, Chengguo Jia, Jianchun Qin,* Lanping Guo*. Marine Natural Products: the Important Resource of Biological Insecticide. Chemistry & Biodiversity, DOI: 10.1002/cbdv.202001020, 2021（通讯作者）

(16) Chenggang Song, Xing Wang, Jian Yang, Yi Kuang, Yuxuan Wang, Shengxiang Yang,* Jianchun Qin,* Lanping Guo*Antifungal Biphenyl Derivatives from Sorbus pohuashanensis Leaves Infected by Alternaria tenuissi and Their Effect against Crop Pathogens Chemistry & Biodiversity, DOI: 10.1002/cbdv.202100079, 2021（通讯作者）

(17) Dandan gao, Zhimin guo, Jiabin Wang, gaofeng hu, Yuqiao su, lijun chen, Qianwen lv, huimei Yu, Jian-Chun Qin*.Dicerandrol B: a natural xanthone dimmer induces apoptosis in cervical cancer hela cells through the endoplasmic reticulum stress and mitochondrial damage. OncoTargets and Therapy, 12: 1185-1193, 2019（通讯作者）

(18) Sheng-Xiang Yang, Cheng-Gang Song , Yi Kuang , Bing Liu, Yan-Xin Zhang ,Ming-Zhe Zhang, Gang Ding, Jian-Chun Qin*. Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada. molecules, 25: 1222-1226, 2020（通讯作者）

(19) Chenggang Song, Gang Ding, Gang Wu, Jian Yang, Mingzhe Zhang, Haoyu Wang, Dongsheng Wei , Lanping Guo, Jian-Chun Qin*. Identification of AUnique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum., Seeds. Chemistry & Biodiversity, 10.1002/cbdv.201900744, 2020（通讯作者）

(20) Chen Lin‡, Jian-chun Qin‡, Yong-gang Zhang* and Gang Ding*. Diagnostically analyzing1 H NMR spectra of sub-types in chaetoglobosins for dereplication. RSC Advances, 10(4): 1946-1955, 2020（并列1作）

(21) H. Y. Wang , M. Z. Zhang , X. Han , J. Cong , S. Q. Wang , S. L. He , D. S. Wei , Y.B. Zhang , Jian-Chun Qin*. Insecticidal and repellent efficacy of the essential oil from Lobularia maritima and trans-3-pentenenitrile against insect pests of stored grains. International Journal of Food Properties, 23:1, 1125-1135, 2020（通讯作者）

(22) Sheng-xiang Yang，Bing Liu， Mei Tang，Jian Yang，Yi Kuang ， Ming-zhe Zhang， Chun-ying Zhang，Chao-yi Wang, Jian-Chun Qin*. Extraction of flavonoids from Cyclocarya paliurus(Juglandaceae) leaves using ethanol/salt aqueous two-phasesystem coupled with ultrasonic. J Food Process Preservy, DOI: 10.1111/jfpp.14469, 2020（通讯作者）

(23) Chenggang Song, Juan Liu, Haoyu Wang, Xiang Li, Bing Liu, Mingzhe Zhang,Xiaohui Shan, He Li, Jinming Gao,* and Jianchun Qin*. New Derivatives from Microbial Transformation of ent-Kaur-16-en-19-oic Acid by Cunninghamella echinulate. Chemistry & Biodiversity, DOI: 10.1002/cbdv.202000178, 2020（通讯作者）

(24) Shuliang He, Yamei Zhang, Yuhe Ma, Dongsheng Wei, Jian-Chun Qin*. Chemical composition and insecticidal activities of the essential oil from fruits of Euonymus schensianus. Chemistry of Natural Compounds, 55(4): 748-750, 2019（通讯作者）

(25) Shuliang He, Dacheng Wang, Yamei Zhang, Shengxiang Yang, Xiang Li, Dongsheng Wei, Mingzhe Zhang, Jian-Chun Qin*. Chemical Components and Biological Activities of the Essential Oil from Traditional Medicinal Food, Euryale ferox Salisb., Seeds. Journal of Essential Oil Bearing Plants, 22(1):73-81, 2019（通讯作者, SCI）

(26) Juan Yang, Xu Han, Hao-Yu Wang , Jian Yang, Yi Kuang, Kai-Yue Ji, Yi Yang, Kai Pang, sheng-Xiang Yang, Jianchun Qin*. Comparison of metabolomics of Dendrobium officinale in different habitats by PLC-Q-TOF-MS. Biochemical Systematics and Ecology, 89:104007, 2020（通讯作者）

(27) Xiangshuai Li, Junyou Han，Xin Wang, Yanxin Zhang, Chengguo Jia, Jianchun Qin, Chunyu Wang, Jia-Rui Wu, Wenhui Fang and Ying-Wei Yang. A triple-stimuli responsive hormone delivery system equipped with pillararene magnetic nanovalves. Materials chemistry frontiers, 3(1): 103-110, 2019（SCI）

(28) Yanxin Zhang, Chengguo Jia, Yamei Zhang, Shengxiang Yang, Yixiao Dong, Dongsheng Wei, Jinzhu Sun, Siqi Wang, Shuliang He, Jie Li, Yuhe Ma, Jian-Chun Qin*. Chemical variability in volatile composition among five species of genus Solidago (Asteraceae). Biochemical Systematics and Ecology, 84: 42-46, 2019（通讯）

(29) Xiangmei Tan, Xiaoyan Zhang, Meng Yu, Yongtao Yu, Zhe Guo, Ting Gong, Shubin Niu, Jianchun Qin, Zhongmei Zou, Gang Ding. Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis. Phytochemistry, 164: 154-161, 2019

(30) Xiang Li, Ye Tian, Sheng-Xiang Yang, Ya-Mei Zhang, Jian-Chun Qin*. Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1. Bioorganic & Medicinal Chemistry Letters, 23(10): 2945-2947, 2013（通讯作者）

(31) Jinliang Liu, Fengting Wang, Gang Yu, Xianghui Zhang, Chengguo Jia, Hongyu Pan，Jianchun Qin*. Functional Analysis of the Maize C-Repeat/DRE Motif-Binding Transcription Factor CBF3 Promoter in Response to Abiotic Stress. Int. J. Mol. Sci. 2015, 16, 12131-12146. （通讯作者）

(32) Da-Cheng Wang, Ya-Mei Zhang, Xiang Li, Hong-Yu Pan, Meng-Yuan Chang, Tian-Yu Zheng, Jin-Zhu Sun, Da-ren Qiu, Ming-Zhe Zhang, Dong-Sheng Wei,  Jian-Chun Qin*. Potential allelopathic azaphilones produced by the endophytic Chaetomium globosum TY1 inhabited in Ginkgo biloba using the one strain−many compounds method Natural Product Research, 2017, 31(6)724-728.（通讯作者）

(33) Daren Qiu, Dacheng Wang, ShengXiang. Yang, Yamei Zhang, Dongsheng Wei, Mingzhe Zhang,Jiangchun Qin*.. Chemical constituents from the fruits of Rhus typhina L. and their chemotaxonomic significance. Biochemical Systematics & Ecology, 2016, 69:261-265 （通讯作者）

(34) Jian-Chun Qin, Ya-Mei Zhang, Chen-yong Lang, Yan-Hua Yao, Hong-Yu Pan, Xiang-Li*. Cloning and functional characterization of a caffeic acid O-methyltransferase from Trigonella foenum -graecum L. Molecular Biology Reports, 39(2):1601-1608, 2012

(35) Jian-Chun Qin, Lin Zhu, Ming-Jun Gao, Xian Wu, Hong-Yu Pan, Yan-Sheng Zhang, Xiang-Li*. Cloning and functional characterization of a chalcone isomerase from Ttigonella oenum-graecum L.f . Planta Medica , 77(7):765-770, 2011

(36) Xiang Li1, Jian-Chun Qin1, Qing-Yu Wang, Xian Wu, Chen-Yong Lang, Hong-Yu Pan, Gruber, Margaret Y, Ming-Jun Gao*. Metabolic engineering of isoflavone genistein in Brassica napus with soybean isoflavone synthase, Plant Cell Reports, 30(8): 1435-42, 2011（1并列第一作者）

(37) Jian-Chun Qin, Hua Su, Ya-Mei Zhang, Jin-Ming Gao, Lin Zhu, Xian Wu, Hong-Yu Pan, Xiang Li*. Highly brominated metabolites from marine red alga Laurencia similes inhibit protein tyrosine phosphatase 1B. Bioorganic & Medicinal Chemistry Letters, 20(23): 7152-7154, 2010

(38) Li-Feng Zan1, Jian-Chun Qin1; Ya-Mei Zhang, Yan-Hua Yao, Hai-Ying Bao, Xiang Li*. Antioxidant hispidin deriviatives from medicinal mushroom Inonotus hispidus. Chemical & Pharmaceutical Bulletin, 59(6):770-772, 2011 ( 1并列第一)

(39) Jian-Chun Qin*, Jin-ming Gao*, Gennaro Pescitelli, Sebastiano Di Pietro, Ya-Tuan Ma, An-Ling Zhang. Structure and absolute configuration of toxic polyketide pigments from the fruiting bodies of the fungus Cortinarius rufo-olivaceus. Orgnic & Biomolecular chemistry, 8(15): 3543-3551, 2010

(40) Jian-Chun Qin, Ya-Mei Zhang, Jin-Ming Gao, Ming-Sheng Bai, Sheng-Xiang Yang, Hartmut Laatsch*, An-Ling Zhang. Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorganic & Medicinal Chemistry Letters, 19(6):1572-1574, 2009

(41) Jian-Chun Qin, Ya-Mei Zhang, Ling Hu, Ya-Tuan Ma, Jin-Ming Gao*, Cytotoxic Metabolites produced by Alternaria No.28, an endophytic fungus isolated from Ginkgo biloba. Natural Product Communications, 4 (11):1473-1476, 2009

(42) Jian-Chun Qin, Jin-Ming Gao, Ya-Mei Zhang, Sheng-Xiang Yang, Ming-Sheng Bai, Ya-Tuan Ma, Hartmut Laatsch*. Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba. Steroids, 74(9) : 786-790, 2009

(43) Dacheng Wang, Suhu Sun, Lina Shi, Daren Qiu, Xiang Li, Dongsheng Wei, Yamei Zhang , Jian-Chun Qin*.Chemical composition, antibacterial and antioxidant activity of the essential oils of Metanicaplexis japo and their antibacterial components. International Journal of Food Science & Technology, 2015，50，449-457（通讯作者）

(44) Da-Cheng Wang, Da-Ren Qiu, Li-Na Shia, Hong-Yu Pan, Ya-Wei Li, Jin-Zhu Sun, Ying-Jie Xue, Dong-Sheng Wei, Xiang Li, Ya-Mei Zhang & Jian-Chun Qin*. Identification of insecticidal constituents of the essential oils of Dahlia pinnata Cav. against Sitophilus zamaeis and Sitophilus oryzae Natural Product Research, 2015, 29(18)1748-1751.（通讯作者）

学术荣誉（Awards and Honors）

国家级涉农领域重大人才支持计划（国家首批神农英才入选者）

吉林省第十六批享受政府津贴专家（省有突出贡献专家）

吉林省第三批拔尖创新人才

吉林省“18条”政策人才

澳门尼威斯人国家杰出青年科学基金后备人才

澳门尼威斯人青年骨干教师培养计划

葫芦巴薯蓣皂苷等次生代谢产物的生物合成基因的克隆和功能基因验证，吉林省自然科学二等奖，2013

植物及其内生真菌活性次生代谢产物的发现及生物合成等研究，吉林省自然科学三等奖，2016

核盘菌子实体形成机制及大豆菌核病综合防控技术的研究与应用，吉林省科学技术一等奖，2013

吉林省“优秀硕士学位论文奖”指导教师

澳门尼威斯人“优秀毕业论文（设计）奖”指导教师

澳门尼威斯人“大员工创新创业训练计划”国家级项目指导教师

代表性著作（Author of books）

《植物化学》第二版，高等院校“十二五”规划教材，国家精品课程配套教材，2012，副主编，科学出版社，58万字。